CALL FOR PAPERS Mitochondrial Metabolism Effects of mtDNA in SHR-mt versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction
نویسندگان
چکیده
Josef Houštěk, Marek Vrbacký, Kateřina Hejzlarová, Václav Zídek, Vladimír Landa, Jan Šilhavý, Miroslava Šimáková, Petr Mlejnek, Ludmila Kazdová, Ivan Mikšík, Jan Neckář, František Papoušek, František Kolář, Theodore W. Kurtz, and Michal Pravenec Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic; Institute for Clinical and Experimental Medicine, Prague, Czech Republic; and Department of Laboratory Medicine, University of California, San Francisco, California
منابع مشابه
Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction.
Common inbred strains of the laboratory rat can be divided into four major mitochondrial DNA (mtDNA) haplotype groups represented by the BN, F344, LEW, and SHR strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. F344 mtDNA by comparing the SHR vs. SHR-mt(F344) conplastic strains that are genetically identical except for their mitochondrial genomes...
متن کاملNonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.
Common inbred strains of the laboratory rat can be divided into four different mitochondrial DNA haplotype groups represented by the SHR, BN, LEW, and F344 strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. LEW mitochondrial genomes by comparing the SHR to a new SHR conplastic strain, SHR-mt(LEW); these strains are genetically identical except fo...
متن کاملConstruction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria.
Because of the lack of appropriate animal models, the potentially causal contributions of inherited mitochondrial genomic factors to complex traits are less well studied compared with inherited nuclear genomic factors. We previously detected variations between the mitochondrial DNA (mtDNA) of the Dahl salt-sensitive (S) rat and the spontaneously hypertensive rat (SHR). Specifically, multiple va...
متن کاملInsulin, thyroid hormone, and heart function of diabetic spontaneously hypertensive rat.
Diabetes impairs cardiac performance more extensively in hypertensive rats than it does in nonhypertensive strains. A "low thyroid state" may contribute to the adverse cardiovascular effects of diabetes in spontaneously hypertensive rats (SHR). We tested this hypothesis by comparing the effects of thyroid hormone with those of insulin treatment on cardiac performance of diabetic SHR. Diabetes w...
متن کاملNutritional and cardiovascular profiles of normotensive and hypertensive rats kept on a high fat diet.
BACKGROUND Although a high fat diet (HFD) promotes nutritional and heart disorders, few studies have assessed its influence in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). OBJECTIVE To evaluate and compare the nutritional and cardiovascular profiles of WKY and SHR on a high fat diet. METHODS 20 WKY and 20 SHR were divided into four groups: Control-WKY (C-W...
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